Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment?

Immune-resistant pancreatic islets hold great promise for advancing diabetes cell therapy. Two key approaches, hypoimmunogenic pluripotent stem cells (PSCs) and hypoimmunogenic cadaveric islets, aim to overcome immune rejection in islet transplantation.
Go to the profile of Essam Abdelalim
Essam Abdelalim
Professor, Sidra Medicine
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Our new review article, just published in Cellular and Molecular Biology Letters, discusses recent and exciting advances in the development of hypoimmunogenic islets for diabetes cell therapy.

We explore two major strategies:

  • Hypoimmunogenic pluripotent stem cell–derived islets
  • Hypoimmunogenic cadaveric islets

Both approaches aim to overcome one of the greatest challenges in islet transplantation — immune rejection — by leveraging cutting-edge gene-editing technologies to create immune-evasive cells. These advances hold great promise for the development of “off-the-shelf” cell therapies that could one day eliminate the need for long-term immunosuppression in patients with diabetes.

The review also highlights:

  • Key breakthroughs in genome engineering of PSCs and cadaveric islets
  • Clinical progress, including the first patient trial using hypoimmune cadaveric islets
  • Current challenges and safety considerations for effective clinical translation

Read the full article here: https://rdcu.be/eJxKo 

Go to the profile of Essam Abdelalim
Essam Abdelalim
Professor, Sidra Medicine

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Developmental Biology and Stem Cells
Life Sciences > Biological Sciences > Developmental Biology and Stem Cells
Biomedical Engineering and Bioengineering
Technology and Engineering > Biological and Physical Engineering > Biomedical Engineering and Bioengineering
Cell Therapy
Life Sciences > Biological Sciences > Biotechnology > Biologics > Cell Therapy
Diabetes
Life Sciences > Health Sciences > Clinical Medicine > Diseases > Diabetes

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