This Special Collection of the Journal of Cannabis Research delves into the intricate world of cannabis, exploring the multifaceted mechanisms through which its diverse array of compounds interact with the human body and their potential therapeutic benefits. Cannabis, a plant with a long and complex history of human use, has garnered significant attention in recent years from the scientific community due to its potential to treat a wide range of medical conditions. This renewed interest has led to a surge in research aimed at elucidating the complex interplay between cannabis compounds and human physiology.

The Collection will focus on the following key areas:

• Phytochemical Diversity: A comprehensive examination of the various cannabinoids, terpenes, and flavonoids found in cannabis, exploring their individual properties and potential synergistic effects. This includes investigations into the unique chemical profiles of different cannabis chemovars and their potential therapeutic applications.

• Endocannabinoid System and non-endocannabinoid Interactions: A detailed analysis of how cannabis compounds interact with the endocannabinoid system and the broad range of receptors or neurotransmitters beyond the endocannabinoid system as well.

• Pharmacological Effects: An exploration of the diverse pharmacological effects of cannabis, including its analgesic, anti-inflammatory, anxiolytic, antiemetic, and neuroprotective properties. This includes preclinical and clinical studies investigating the therapeutic potential of cannabis for various conditions such as chronic pain, epilepsy, multiple sclerosis, anxiety disorders, and cancer.

• Therapeutic Applications: A critical evaluation of the current clinical evidence supporting the use of cannabis for specific medical conditions. This includes systematic reviews, meta-analyses, and randomized controlled clinical trials assessing the efficacy and safety of cannabis-based therapies.

• Drug Development and Delivery Systems: An examination of the latest advancements in cannabis-based drug development, including novel formulations, delivery systems, and personalized approaches to cannabis therapy. This includes research on synthetic cannabinoids, targeted drug delivery, and the development of standardized cannabis extracts.

Possible topics to be included:

• The role of the endocannabinoid system in health and disease

• The therapeutic potential of cannabinoids for neurological disorders

• Cannabis and mental health: implications for anxiety, depression, and PTSD

• The use of cannabis in palliative care and cancer treatment

• Cannabis-based drug development and clinical trials.

This Special Collection provides a comprehensive overview of the current state of knowledge regarding the mechanisms of action and potential therapeutic applications of the cannabis plant. By bringing together innovative research from leading experts in the field, we hope to stimulate further inquiry and contribute to the development of safe and effective cannabis-based therapies for the benefit of patients worldwide.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.

This Collection focuses on the latest advancements in Cannabis sativa research, aiming to provide a comprehensive understanding of the key aspects that drive its production and utility. Cannabis, renowned for its diverse array of bioactive compounds, has garnered significant attention across scientific, agricultural, and industrial domains. This Collection invites original research, reviews, and perspectives on the following themes:

• Molecular Insights: exploring the genetic and transcriptomic mechanisms underlying cannabinoid and terpenoid biosynthesis, as well as glandular trichome development

• Germplasm Resources: studies on genetic diversity, breeding strategies, and innovative approaches for developing high-yield and specialized chemotype cultivars

• Plant Physiology: investigations into physiological responses to environmental stimuli, metabolic pathways, and signaling processes relevant to growth and secondary metabolite production

• Agronomic Practices: sustainable and optimized cultivation techniques, including light, nutrient, and stress management strategies, aimed at maximizing yield and quality in controlled and open-field systems.

This Collection serves as a platform for scientists, breeders, and industry stakeholders to share breakthroughs and collaborative insights. Together, these contributions will advance our understanding of cannabis biology and production, fostering innovation in this rapidly evolving field.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.