This Collection focuses on advances in stem cell biology, including pluripotent stem cells, induced pluripotent stem (iPS) cells, and adult stem or progenitor cells, as well as their applications in regenerative medicine, particularly within the fields of cardiovascular biology, skeletal muscle repair, and cardioimmunology. We aim to include mechanistic and translational research that explores how stem cell based approaches modulate inflammation, fibrosis, vascular remodeling, and functional tissue regeneration.

The Collection welcomes original experimental studies (in vitro, in vivo, human, and animal models), as well as innovative methodological papers related to stem cell differentiation, tissue engineering, and advanced cell-based therapies. Highly focused systematic reviews or meta-analyses may be considered, although original research articles will be prioritized. Topics of interest also include fibro-adipogenic progenitors (FAPs), immune and stem cell interactions, engineered tissues, biomaterials, and preclinical models of regenerative strategies.

All submissions in this Collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.

A significant body of evidence suggests that culture expanded mesenchymal stromal cells (MSCs) are short-lived, paracrine signalers that briefly calm inflammation following in vivo administration before disappearing. However, emerging preclinical and early clinical evidence suggests that MSCs may also induce longer-term immunological changes through mechanisms such as trained immunity and epigenetic imprinting of hematopoietic or precursor stem cells in the bone marrow.

This Collection welcomes original research or review articles describing novel findings and insights on immune re-programming mediated by MSCs and evidence of long-term effects in vivo.

All submissions in this Collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.