Stem cells in organogenesis and regeneration

Stem cells drive organogenesis and regeneration by supplying specialized cells for development, tissue maintenance, and repair. This overview highlights major stem cell types, their sources, and key stages of organ formation governed by stem cell activity.
Go to the profile of Dr. ksuresh babu
Dr. ksuresh babu
Professor, Symbiosis Medical College for women/Symbiosis international university
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https://link.springer.com/article/10.1186/s13287-025-04889-z

This review summarizes the fundamental role of stem cells in organogenesis, tissue maintenance, and regeneration. It outlines major stem cell types and their sources, emphasizing key signaling pathways—Wnt, Notch, Hedgehog, and BMP—that govern stem cell fate and lineage specification. The roles of embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells in organ formation and tissue repair are discussed, along with advances in directed differentiation. The review highlights organoids as powerful models for studying development and disease, examines stem cell niches and microenvironmental regulation, and reviews translational progress, clinical applications, challenges, emerging technologies, and ethical considerations in stem-cell-based therapies.

Go to the profile of Dr. ksuresh babu
Dr. ksuresh babu
Professor, Symbiosis Medical College for women/Symbiosis international university

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Stem Cell Biology
Life Sciences > Health Sciences > Biomedical Research > Stem Cell Biology

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