Graham Hatfull

Professor, University of Pittsburgh
  • United States of America

About Graham Hatfull

Microbiology, phage biology, phage genomics, mycobacteria, science education

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May 14, 2019

I recognize that there are a series of issues arising when using derivatives of temperate phages therapeutically. We would recommend the removal of  the integration apparatus in addition to the repressor if intending to convert a former temperate phage into one that could be considered for therapy.  But with designer-therapies there is also often a time constraint.

Just to clarify, the same cocktail was not used for a second patient with a failed outcome. The same cocktail was not useful for other patients due to strain specificity of the phage susceptibility profiles.