About Lewis Zhichang Shi
Immuno-metabolism, Cancer Immunotherapy, T cell biology
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Overcoming immunotherapy resistance in melanoma defective of IFN-g signaling
Melanoma loss of IFN-g signaling is a major mechanism of resistance to immune checkpoint blockers such as anti-CTLA-4 and anti-PD-1, a prominent type of immunotherapies offering unprecedented therapeutic hopes to melanoma patients. However, strategies of overcoming this resistance have been elusive.
Recent Comments
I woud lik to share our most recently published story with the research community, wherein we report an indispensable role of HIF1a in driving IFN-g induction in hypoxic T cells and anti-tumor immunity elicited by immune checkpoint blockade therapies.