Lihui Guo works in the Lung Group at the Dept. of Pulmonary Medicine and the Dept. of Experimental Immunology, Amsterdam UMC, University of Amsterdam.

Research focuses on the role of IDO1/2 in infectious diseases, such as tuberculosis, tuberculous meningitis (TBM), fatal/severe COVID-19, and post-COVID, post-acute sequelae of SARS-CoV-2 infection (PASC), also called “long COVID”.

I am also deeply passionate about pathology, particularly in the realm of Neutrophil Extracellular Traps (NETs) and the impact of tryptophan metabolic stress on infectious diseases. Additionally, my interests extend to the study of Allergy (MMP-12) and innovative treatments for Esophagogastric Cancer (EGC).

As of tuberculosis (M. tuberculosis), using cell lines, a murine model, zebrafish model, and IHC staining lung and Brain from TB patients, particularly focus on the role of IDO1 activity in macrophages protects M. tuberculosis from being killed by antibiotics, the role of IDO1 activity in manipulated apoptosis of M. tuberculosis infected macrophages, and using EM to study M. tuberculosis translocation within macrophages.