FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma
RCC exhibits defects in homologous recombination and oxidative DNA damage. Our study shows that PRR11, upregulated in RCC, promotes proliferation and migration via AKT signaling. This activation inhibits GSK3β/FBXW7-mediated PRR11 degradation, forming a feedback loop that worsens RCC progression.