HIV affects polyamine metabolism and T cell lineages
How HIV induces alterations in polyamine metabolism and could affect T cells and their functions in the oral mucosa of HIV-infected individuals.
Pushpa Pandiyan (She/Her)
Professor, Case Western Reserve University
- United States of America
About Pushpa Pandiyan
I am a Mucosal Immunologist, mainly focusing on infection and cancer immunology in the oral mucosa. We are doing omics approaches to study the intricacies of immune cell interactions during health and disease. My research goal is to develop a multidisciplinary research program that is committed to (i) understanding how Tregs and Th17 cells interact with microbiome, innate immunity, and cancer cells in the mucosa (ii) elucidating epigenetic/transcriptomic/metabolomic molecular pathways that determine the population size and function of Tregs, Th17 cells and other immunoregulatory cells, (iii) characterizing them in normal individuals, patients with oral and gut mucosal immune diseases, HIV infection, and cancer (iv) developing immuno-therapeutic agents to control these cells for treating immuno-pathology and cancer. I am thoroughly excited and humbled by our recent findings on novel mechanisms of immune dysfunction during HIV disease and cancer.
Bhaskaran N, Jayaraman S, Quigley C, Mamileti P, Ghannoum M, Weinberg A, Thuener J, Pan Q, Pandiyan P. The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging. Frontiers in Oncology. 2021 Apr 22;11:669066. PMID: 33968777, PMCID: PMC8100664, DOI: 10.3389/fonc.2021.669066.
Bhaskaran, N, Schneider, E, Faddoul, F, Paes da Silva, A, Asaad, R, Talla, A, Greenspan, N, Levine, AD, McDonald, D, Karn, J, Lederman, MM, and Pandiyan, P. Oral immune dysfunction is associated with the expansion of FOXP3 + PD-1 + Amphiregulin + T cells during HIV infection. Nature Communications. 2021 Aug 26;12(1):5143. doi: 10.1038/s41467-021-25340-w. PMID: 34446704 PMCID: PMC8390677.
Pandiyan, P and McCormick TS. Regulation of IL-17A-Producing Cells in Skin Inflammatory Disorders. J Invest Dermatol. 2021 (21) 01673-0.doi: 10.1016/j.jid.2021.06.036. PMID: 34561088.
Mahalingam,SS, Jayaraman, SJ, Pandiyan, P. Fungal Colonization and Infections—Interactions with Other Human Diseases. Review. Pathogens 2022, 11(2), 212; PMID: 35215155; PMCID: PMC8875122. https://doi.org/10.3390/pathogens11020212.
Shive C and Pandiyan P. Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly. Frontiers in Aging, 2022 Apr 27;3:840827. PMID: 35821823 PMCID: PMC9261323 DOI: 10.3389/fragi.2022.840827.
Mahalingam, SS, Jayaraman, S, Bhaskaran, N, Schneider, E, Faddoul, F, Paes da Silva, A, Lederman, MM, Asaad, R, Adkins-Travis K, Shriver LP, and Pandiyan, P. Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV. Nat Communications. 2023 Jan 25;14(1):399. PMID: 36693889 PMCID: PMC9873639 DOI: 10.1038/s41467-023-36163-2.
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