Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Sea level rise in the Mediterranean Sea, a first victim
AUTHORS: Aurélie Blanfuné, Charles-François Boudouresque, Marc Verlaque, Antoine Minne, Fanny Noisette, Thierry Thibaut
Culture-associated DNA hypermethylation of CAR T cells negatively affects therapeutic outcome
Analyzing effects of vitro expansion on the methylome of chimeric antigen receptor (CAR) T cells revealed loci with increased methylation that were also associated with reduced long-term survival in patients. These findings suggest that reduced cultivation periods may benefit clinical outcome.