Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Flexibility meets quality and scale
Finding solutions to all of these challenges was a major bottleneck for the burgeoning field of single-cell mass spectrometry proteomics.
Filling the spectral gap of persistent luminescence
By engineering sub-bandgap donor-acceptor states within a series of single-phase Ca(Sr)ZnOS crystals, the persistent luminescence emission peak can now be quasi-linearly tuned across a broad wavelength range (500–630 nm) as a function of Sr/Ca ratio.
PTMGPT2: An Interpretable Protein Language Model for Enhanced Post-Translational Modification Prediction
PTMGPT2 uses GPT-based architecture and prompt-based fine-tuning to predict post-translational modifications. It outperforms existing methods across 19 PTM types, offering interpretability and mutation analysis. This advances the understanding of protein function and disease research.
Mutation in Bruton Tyrosine Kinase (BTK) A428D Confers Resistance To BTK-Degrader Therapy In Chronic Lymphocytic Leukemia
Drugs that target BTK for proteasomal degradation, so-call BTK degraders, are presumed able to mitigate the risk of drug resistance due to BTK mutations. In Leukemia 38:1818 (2024), Kipps and colleagues describe a patient who developed resistance to the BTK-degrader BGB-16673 via a mutation in BTK.
