About Yu Xiao

Researcher at Department of Urology and Biobank focussing on Oncology, Cell Biology, Bioinformatics for pre-clinical study.

Intro Content

Behind the Paper

Integrative single cell atlas revealed intratumoral heterogeneity generation from an adaptive epigenetic cell state in human bladder urothelial carcinoma

A subgroup of bladder cancer cells marked by TM4SF1 expression is a key source of tumor diversity (ITH). These cells, which show stem-cell features and foster various cell types within the tumor, are linked to more advanced cancer stages and poorer outcomes.

Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis

Melatonin may help fight bladder cancer (BLCA) by slowing cancer cell energy production and increasing chemotherapy effectiveness, by targeting ENO1 to enhance gemcitabine’s impact and involving reactive oxygen species and PPARγ regulation. This suggests new methods for improving BLCA treatment.

Yu Xiao and 4 others

Oct 20, 2024

Behind the Paper

Conditional reprogramming: Modeling urological cancer and translation to clinics

Patient-derived conditional reprogramming (CR) lets cells grow indefinitely, aiding in studying cancer, developing treatments, and advancing personalized medicine. This approach shows promise for improving urological cancer treatment.

Yu Xiao and 3 others

Oct 18, 2024

Behind the Paper

DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization

Our study shows that DLGAP5 enhances gemcitabine resistance in bladder cancer by stabilizing MYC protein via USP11-mediated deubiquitination. This interaction boosts MYC-driven glycolysis, suggesting that targeting the DLGAP5-USP11-MYC axis could overcome resistance.

Yu Xiao and 4 others

Jan 20, 2025

Nature Communications

Behind the Paper

DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

Based on the bladder cancer (BLCA) pedigree containing germline mutation of POLD1 found in our last study, we further analyzed the molecular role of POLD1 driving tumorigenesis. We identified POLD1 as a promotor of BLCA via a MYC driven mechanism.

Yu Xiao and 3 others

Oct 11, 2024

Oncogene

Behind the Paper

MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3

Our research reveals that MYBL2, a gene-regulating protein, is elevated in bladder cancer (BLCA) and linked to worse patient outcomes. It boosts BLCA growth and spread by activating the CDCA3 gene, working with FOXM1 to enhance cancer traits. This identifies MYBL2 as a key promoter of BLCA.

Yu Xiao and 3 others

Oct 18, 2024

Cell Death & Disease

Behind the Paper

USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer

This study identified USP43 as a deubiquitinase which regulates glycolytic metabolism and c-Myc transcriptional activity and revealed a USP43/c-Myc positive feedback loop that contributes to the progression of BLCA.

Yu Xiao and 2 others

Jan 14, 2024

Cell Death Discovery

Behind the Paper

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Pectolinarigenin (PEC) from herbal medicine targets DNA topoisomerase II alpha (TOP2A) in bladder cancer (BLCA), causing DNA damage and blocking cell division. It inhibits autophagy, boosting its effectiveness. Combined with gemcitabine, PEC more effectively halts BLCA growth.

Yu Xiao and 4 others

Oct 20, 2024

Behind the Paper

Concurrent DNA hypomethylation and epigenomic reprogramming driven by androgen receptor binding in bladder cancer oncogenesis

CUT&Tag sequencing reveals how the androgen receptor (AR) drives tumor heterogeneity and gender disparities in bladder cancer through epigenetic reprogramming.

Yu Xiao and 3 others

Dec 28, 2024

Oncogene

Behind the Paper

A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype

This study is the first report identifying a pathogenic EGFR germline mutation in prostate cancer, suggesting venues for germline screening, non-invasive diagnosis and monitoring in clinical practice.

Yu Xiao and 3 others

Oct 16, 2024

Oncogene

Behind the Paper

TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC

This study identified the significant role of TRAIP in inhibiting BLCA progression, and revealed that TRAIP expression is significantly downregulated in BLCA and is strongly associated with poor prognosis.

Yu Xiao and 2 others

Dec 21, 2023

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Behind the Paper

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Yu Xiao (He/Him)

About Yu Xiao

Intro Content

Integrative single cell atlas revealed intratumoral heterogeneity generation from an adaptive epigenetic cell state in human bladder urothelial carcinoma

Popular Content

Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis

Conditional reprogramming: Modeling urological cancer and translation to clinics

DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization

DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3

USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Concurrent DNA hypomethylation and epigenomic reprogramming driven by androgen receptor binding in bladder cancer oncogenesis

A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype

TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC

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