Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
Overcoming Chemotherapy Resistance in Head and Neck Cancer using PI3K Inhibition
Head and neck squamous cell carcinoma (HNSCC) is almost uniformly fatal when it recurs following definitive treatment with chemoradiation. To address this critical therapeutic gap, our team investigated inhibition of the phosphoinositide 3-kinase (PI3K) pathway.
Rein in or Ruin: Ubiquitylation of CDC42 Ensures Membrane Homeostasis and Regulates Brain Development
The small Rho GTPase CDC42 drives actin polymerization and membrane protrusion. Unchecked cytoskeletal remodeling can push tumor cells toward EMT or even cell death. Thus, elucidating how cells both activate and quench CDC42 signaling to maintain membrane homeostasis has been a central question.
Breaking the Silence: Ethnic Inequalities in Cancer Pain Relief in the UK
Our study, published in the British Journal of Cancer, reveals patients with cancer from minority ethnic backgrounds in England are prescribed fewer opioids for pain relief at the end of life and require more emergency department visits, highlighting urgent inequalities in palliative care
Real-world evaluation of cinacalcet on hard outcomes in hemodialysis patients in Saudi Arabia
Chronic kidney disease affects ~10% globally and can cause secondary hyperparathyroidism, a disorder that disrupts mineral and bone metabolism and significantly raises cardiovascular risk-the leading cause of death in dialysis patients.
