Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
Single cell snapshot analyses under proper representation reveal that epithelial-mesenchymal transition couples at G1 and G2/M
Numerous computational approaches have been developed to infer cell state transition trajectories from snapshot single-cell data. With the fast-accumulating computational methods that have been developed, several fundamental issues have been rarely investigated, which is the focus of this study.
From Refusal to Recovery: What One Family Taught Us About Health Literacy in TB
One patient’s refusal to take TB medicine despite counselling exposed a deeper issue: a gap in health literacy. Our study investigates how this gap impacts patients especially those with comorbidities and what it means for TB elimination in India.
Secondary data use of tocilizumab clinical studies to address regulatory needs for rare and pediatric trials
As part of the European INVENTS research project (Innovative designs, extrapolation, simulation methods and evidence-tools for rare and pediatric diseases), a study involving the use of secondary data from 10,000 patients in 20 clinical studies has been registered in the ISRCTN registry.
Comparison of transient elastography and shear wave elastography as a routine diagnostic method for assessing liver fibrosis in Indian participants with liver steatosis
Liver health is one of the biggest health challenges in India. Millions of people—often without any symptoms—have fatty liver disease. While fatty liver itself may sound harmless, it can gradually progress to liver scarring (fibrosis), liver failure, or even liver cancer if not detected in time.
Why building AI for healthcare requires stakeholders, not just a dataset
Should AI simply reflect the reality of a healthcare system, or should it help us reform it? This is the story of how we learned that for AI to be truly equitable, the process of building it is just as important as the final chatbot.
Building a primary care chatbot with people, not for them
The real challenge wasn't just building a smart chatbot; it was building one humble enough to listen and adapt to the people it was meant to serve.
Mechanistic insights into concurrent cART + 3HP therapy in TB/HIV co-infection
TB and HIV remain two of the world’s deadliest infections, and their convergence creates a uniquely difficult clinical challenge. Our study in rhesus macaques uncovers how early concurrent cART and 3HP therapy shapes immunity, bacterial control, and the risk of TB reactivation.
Sex and Gender Shape Health—Time for Science to Establish Clarity
Our biological sex - physical and physiological traits - and our gender - the roles and identities we take on throughout life - both influence our health. Yet research measuring sex and gender effects remains fragmented, constraining evidence-informed decision-making.
Telemedicine-delivered myofunctional therapy induces measurable upper airway remodeling in OSA
Obstructive sleep apnea is shaped by upper airway anatomy, tongue size and neuromuscular tone. While myofunctional therapy improves outcomes, evidence of airway remodeling is limited. This study evaluates whether telemedicine-delivered myofunctional therapy induces measurable airway changes in OSA
