Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Antibody-displaying extracellular vesicles for targeted cancer therapy
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological signals across tissues. Here, by leveraging these functionalities, we show that EVs decorated with an antibody-binding moiety can be used as a modular delivery system for targeted cancer therapy.
Unlocking the evolutionary mechanism of Intermolecular Diels-Alderases from Mulberry Trees
In organic synthesis, the Diels-Alder reaction is pivotal. Seeking eco-friendly alternatives, researchers explore natural Diels-Alderases, enzymes that catalyze this reaction. Xiaoguang Lei's lab uncovers evolutionary mechanisms in plant-derived Diels-Alderases, especially from mulberry trees.
Smart Clinics in Ophthalmology: Automatic Fundus Fluorescein Angiography Image Interpretation with Large Language Models
FFA-GPT is an automated system for ophthalmic image interpretation that enables both report generation and interactive question answering for fundus fluorescein angiography images.
A(H5N1) Avian Influenza Virus: Issues of Concern in a One Health Perspective
The neurotropism and neuropathogenicity of the A(H5N1) influenza virus in birds and mammals like pinnipeds and cetaceans (1-5) are of concern, along with the rapidly growing number of virus-susceptible animals, including several species phylogenetically distant from each other (6).
Mercury - the invisible contaminant that could be driving population declines among migratory shorebirds along the East Asian-Australasian Flyway
Over one-third of the sampled shorebirds along the East Asian-Australasian Flyway are facing Hg risk. Tringa genus in South China was at the highest risk. Feather Hg was best explained by feathers' moulting region, while habitat preference, diet, and forage stratum were less important.
