Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway
We used molecular, genetic and bioinformatic approaches to determine the mechanism of micronuclei formation induced by two TOP1 poisons (CPT and LMP776) in different human cancer cells, including SCLC cell lines.
Hyperphosphorylated tau polymerizes into amorphous cytotoxic aggregates
One pathological hallmark of Alzheimer’s disease is the accumulation of neurofibrillary tangles that are primarily consisted of hyperphosphorylated tau. Our results highlighted the impact of hyperphosphorylation on tau leading to the spontaneous formation of amorphous cytotoxic aggregates.
Understanding pathoadaptation of the periodontal microbiome
It is now becoming critical to understand how a synergistic community of virulent bacteria can persist below the gum line, modulate inflammatory responses, and promote gum infections and inflammation, with strong implications in several systemic diseases in adults.
Longitudinal and Latitudinal Split-Gate Field-Effect Transistors for NAND and NOR Logic Circuit Applications
Structural engineering of split-gate FET (SG-FET) is carried out to achieve two different homogeneous MoS2-based switching devices, whose SG gap direction are longitudinal (AND-FET) and latitudinal (OR-FET) to the channel direction.
