Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Procyanidin C1 is a natural agent with senolytic activity against ageing and age-related diseases
Advancements of studies with model organisms that cellular senescence drives ageing and age-related pathologies have elicited widespread efforts to identify compounds of a potential to selectively kill senescent cells, now termed as 'senolytics'.
Microgravity and bone physiology: Impacts on skeletal stem/progenitors.
Our paper entitled “Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts” just published in npj Microgravity, reveals how simulated microgravity alters bone at the stem/progenitor level.
Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer
In this clinical study, we have validated a 44 gene expression based DDIR signature as a predictor of response to neoadjuvant chemotherapy in breast cancer, which can be integrated into clinical workflows, and potentially identifies a subgroup of cancers responsive to anthracycline treatment.
