Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
APOBEC3A – a causative agent in cancer-related chromosomal instability and STING driven metastasis
Chromosomal instability (CIN) is a hallmark of cancer and has been associated with a highly metastatic phenotype in numerous cancers. We identified a novel function for APOBEC3A in the initiation of CIN featuring enhanced, STING-dependent, distant organ seeding, and metastatic growth.
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
This post details some of the motivation and concepts of our paper, and why we decided to focus on a different type of observable phenotype within CRISPR genetic screens.