Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Gilteritinib plus CUDC-907 – A Novel Therapeutic Combination with The Ability to Overcome Drug Resistance
In this study, we showed that combining the second-generation FLT3 inhibitor gilteritinib with the dual PI3K/HDAC inhibitor CUDC-907 synergistically improved anti-leukemic activity against FLT3-ITD acute myeloid leukemia (AML) – and that each agent reciprocally overcame resistance to the other drug.
Impact of an accelerated melting of Greenland on malaria distribution over Africa
How can vector-borne diseases be impacted by non-linear climate instabilities, such as a rapid melting of the ice sheet, that can have a strong impact on climate? We try to answer this question by studying the impact of an accelerated melting of the Greenland ice sheet on climate and malaria in Africa.
Plant-like SPX-PHR-PSI regulatory cascade operates in phytoplankton
Phytoplankton are aquatic counterparts of plants, contributing 50% of CO2 drawdown and O2 production. They also are the base of the marine food chain. Like plants, their photosynthesis and growth rely on nutrients such as phosphate. How phytoplankton regulate P nutrition is poorly understood.
