Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
AAV-Mediated In Vivo CAR Gene Therapy for Targeting Human T Cell Leukemia
In a proof-of-principle study published in Blood Cancer Journal, we showed that human CAR T cells can be generated within the host upon injecting an Adeno-associated virus (AAV) vector carrying the CAR gene, which we call AAV delivering CAR gene therapy (ACG).
Raman spectroscopy for real-time and in situ monitoring of mechanochemical milling reactions
Raman spectroscopy is an essential technique of process analytical technologies used in the chemical and biopharmaceutical industry for uninterrupted monitoring of manufacturing processes. Now, it is also a powerful tool for monitoring solid-state milling reactions on vibratory ball mills.
Re-thinking the role of filamentation in systemic candidiasis
Filamentation is considered to be an essential virulence trait of the fungus Candida albicans. Here we show that lack of filamentation can be compensated by enhanced proliferation, leading to lethal candidiasis.
