Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock
A new vaccine technology combining capture of bacterial pathogens with effective immune-reprogramming biomaterials could overcome common limitations in infection medicine.
The emergence of neutralizing antibodies limits success of mycobacteriophage therapy
Mycobacterium abscessus infections present a major challenge to antibiotic therapy. Bacteriophages have a potential role to play in treatment of these infections, but neutralizing antibody reactions can limit the efficacy of the phages when administered intravenously.
Nontuberculous Mycobacterial Infection and Environmental Molybdenum in Persons with Cystic Fibrosis: A Case-Control Study in Colorado
NTM are ubiquitous environmental bacteria that may cause chronic lung disease and are one of the most difficult to treat infections among persons with cystic fibrosis (pwCF). We identified molybdenum in the source water as the most predictive factor of M. abscessus infection among pwCF in Colorado.
An in situ activity assay for lysyl oxidases
Current methods for detecting activity of lysyl oxidases lack specificity and do not provide information on how much activity is occurring in situ. Hydrazide reagents can be used to measure their in situ activity levels in a practicable, sensitive, and specific manner.