Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Engineering “smart” co-cultures
Synthetic biologists are increasingly using co-culture systems, but tools to control the composition of subpopulations are lacking. We designed a co-culture with signal translator and growth controller modules where culture composition autonomously adjusts in response to the AI-2 QS molecule.
The adverse effects of clonal hematopoiesis in multiple myeloma
Tarek H. Mouhieddine, MD
Selecting the most appropriate SpCas9 variants for your own interests
Among the numerous SpCas9 variants that previously reported, we compared 13 variants to provide guidance to researchers. We developed a computational tool that predicts the activities of the variants to provide insights in selecting the most appropriate variants for their own research purposes.
Synthesis and versatile reactivity of scandium phosphinophosphinidene complexes
Due to the energy mismatching between the frontier orbitals of rare-earth metal and ligand atom, the rare-earth metal-phosphorus multiple bonds are very unstable. This Behind introduces our group’s struggling trip to the first rare-earth monometallic phosphinidene complex during the past 10 years.
50 Years of Cetacean Strandings Reveal a Concerning Rise in Chilean Patagonia
By collecting cetacean stranding data from the last 50 years in the Chilean coast, we found that strandings have been increasingly reporting at a higher rate during the last 10 years, particularly at the Patagonia, the southernmost part of Chile.