Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Go with the flow: high throughput 3D localization in cells by depth-encoding imaging flow cytometry
Localizing subcellular objects in 3D at high throughput is a major challenge in microscopy with broad relevance to biology and medicine. By merging two technologies, point-spread-function engineering and imaging flow cytometry, we have accelerated 3D imaging to record large populations of cells.
A stress response pathway promotes immune evasion in lung cancer
Using CRISPR based screening, we discovered that activation of the integrated stress response pathway enhances PD-L1 translation and promotes immune suppression in lung cancer.
