Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Active Autophagy May Be Good for Survivals of Cancer Patients
Mutants in LRPPRC gene was found to be associated with French Canadian Type Leigh syndrome. Here we used a mouse model to confirm that LRPPRC acted through P62 and HDAC6 to activate autophagy and through Yap and P27 to maintain genome stability so that hepatocellular carcinoma was suppressed.
PBRM1: A Potential Negative Predictive Biomarker for immunotherapy in NSCLC
In our research, PBRM1 mutation was found to be a negative predictive biomarker of immunotherapy efficacy in NSCLC. Patients with PBRM1 mutation got less survival benefit from immunotherapy for NSCLC.
