Behind the Paper

The real stories behind the latest research papers, from conception to publication, the highs and the lows

Nature Communications
Behind the Paper

HPV circRNAs: Transformation with no end in sight

Although circular RNAs (circRNAs) are abundant and can be encoded by viruses, the function of most circRNAs remain unclear. We describe the discovery of circRNAs in human papillomaviruses (HPVs) including a circular E7 RNA (circE7). CircE7 is translated and required for transformation in cervical cancer cells, providing strong evidence that circRNAs can be translated and have important biological functions. Jiawei Zhao Richard Wang
Go to the profile of Richard C Wang
Richard C Wang
Jun 11, 2019
npj Digital Medicine
Behind the Paper

A step towards better sleep science: a large sleep-wake scoring benchmark

For many years, sleep-wake scoring algorithms were created and validated with small and private datasets with no more than one hundred participants. In this paper, we devised the largest dataset up to date for the sleep-wake classification problem and analyzed the performance of popular traditional algorithms as well as state-of-the-art machine learning techniques to tackle this problem. By making this dataset public, researchers can use our data and results as a benchmark to develop newer algorithms.
Go to the profile of Joao Palotti
Joao Palotti
Jun 07, 2019

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