Antigen-agnostic tumour tagging for CAR T cell therapy

T cells with a chimaeric antigen receptor specific for fluorescein isothiocyanate can be directed against solid tumours via the intratumoural administration of a fluorescein-isothiocyanate-conjugated amphiphile that inserts itself in cell membranes.

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The cover illustrates that the tagging of tumour cells with an amphiphilic ligand for a chimaeric antigen receptor on T cells allows for the universal redirection of the cells against solid tumours.

See Zhang et al.

Image: Angela Zhang and co-authors. Cover design: Alex Wing.

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Life Sciences > Biological Sciences > Biotechnology