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Nuclear wrinkling and chromatin state mediate stiffness-induced breast cancer

In a 3D model of breast cancer, a stiff extracellular matrix promotes a tumorigenic phenotype through broad changes in chromatin accessibility and in the activity of histone deacetylases and the transcription factor Sp1.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility - Nature Biomedical Engineering

In a 3D model of breast cancer, a stiff extracellular matrix promotes a tumorigenic phenotype through broad changes in chromatin accessibility and in the activity of histone deacetylases and the transcription factor Sp1.

The cover illustrates that a stiff extracellular matrix induces a tumorigenic phenotype in mammary epithelial cells through nuclear wrinkling and broad changes in chromatin accessibility. Image: Dr. Ryan Stowers, University of Santa Barbara. Cover design: Alex Wing.

Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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