Method of the Year 2009

Published in Protocols & Methods

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Thanks again to all our readers who took the time to nominate and vote for methods important for biology.

As you probably know by now (and if you don’t, visit our January special issue), we picked induced pluripotent stem cells as Method of the year 2009 for their potential as tools for studying both disease and basic biology. iPS cells did not in fact do too badly among our voters, coming out fifth, both in total votes and in positive votes.

To read our editorial on iPS cells as tools for biology, go here.

The clear method on top in our voting gallery this year was mass spectrometry-based proteomics: the two top vote getters were a paper using peptide ligand libraries for the analysis of the cytoplasmic proteome of human erythrocytes and a paper using targeted proteomics to analyse the proteome of yeast. We certainly agree that these are areas of a lot of interest and included targeted proteomics as a method to watch.

Considering methods that received a minimum of 20 votes (either positive or negative) as a cut-off, the others that stand out in your votes are label-free imaging, single-molecule detection methods inside of cells and methods for studying genome structure. In this case too, your votes dovetail with our selection of methods to watch, here and here.

We’ve solved some of the problems of the voting process from last year but the numbers of votes are still quite low. We welcome suggestions from you as to how we may improve the process.

And tell us what you think of our selection of iPS cells as tools for biology!

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