We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website. You can decide for yourself which categories you want to deny or allow. Please note that based on your settings not all functionalities of the site are available.
Further information can be found in our privacy policy.
Recent Comments
Hi, excellent and timely research!!!!!
MY THOUGHTS AFTER READING THE PAPER:
Constant pH reading is fundamentally important in chemical properties/solutions because it has the potential of affecting reaction pathways/kinetics with the atmosphere being no exception due to the condensed phase (atmospheric aerosol) pH driving key chemical reactions that can ultimately impact global climate change in varied ways. This brings the urgent need to enhance our understanding of the dynamics of aerosol acidity through experimental measurements that can probe the pH in atmospherically relevant particles for unraveling the connection between chemistry and climate change as well as the minute/latent changes that occurs in chemical reactions which when compounded with other factors can have either immediate or long term implications particularly in the bio-system. It also highlights the need for upgraded work stations as well as comparative studies between reactions performed in opened circuits against those in controlled stations.
This will aid in elucidating the important contribution of atmospheric factors in ''confirmed/approved'' systems/tools particularly therapeutics which can avail different efficacy outcome due to variation in ''micro-atmospheric conditions across geographical locations. It can also be personal, because the electron cloud around every person is unique due to the interference of personal life style habits in addition to locality.
Thank you.
Hi,
Excellent technique and great paper. Just a comment:
the oxidation of state of elements is critical in reporting chemical names of compounds as well as the ionic charge therefore it is a fundamental in chemistry although decoding the oxidation state of a single element is easy, in the case of compounds made up of an array of elements, it is difficult to decipher.
Bond valence theory has been used to evaluate the oxidation state of a compound depending on the distances between the atoms of its constituent elements, but it presents with potential flaws particularly in grouped materials with crystal structures since the geometry of the metal complex also plays an important role in determining the molecular stability as well as valency of the compound. Since reproducibility is a key feature of science thus AI algorithms that can more efficiently determine oxidation states by material categorization and determination of organic frameworks is important in minimizing the error rates in assigning oxidation state to elements/compounds.
Oxidation states has been problematic in research due to latent interactions with host/environmental elements such as reactive oxygen specie/electron cloud thus it plays on shell/half-life of products rendering them less potent in ''latent'' ways and by extension creating variability of response particularly in therapeutics. Correct valency/oxidation state assignment will avail the opportunity for the development of more robust health intervention tools with enhanced predictive response value for progressive science as well as good overall patient outcome both in the inter and intra population level.
Thank you.
Hi,
Excellent technique and great paper. Just a comment:
the oxidation of state of elements is critical in reporting chemical names of compounds as well as the ionic charge therefore it is a fundamental in chemistry although decoding the oxidation state of a single element is easy, in the case of compounds made up of an array of elements, it is difficult to decipher.
Bond valence theory has been used to evaluate the oxidation state of a compound depending on the distances between the atoms of its constituent elements, but it presents with potential flaws particularly in grouped materials with crystal structures since the geometry of the metal complex also plays an important role in determining the molecular stability as well as valency of the compound. Since reproducibility is a key feature of science thus AI algorithms that can more efficiently determine oxidation states by material categorization and determination of organic frameworks is important in minimizing the error rates in assigning oxidation state to elements/compounds.
Oxidation states has been problematic in research due to latent interactions with host/environmental elements such as reactive oxygen specie/electron cloud thus it plays on shell/half-life of products rendering them less potent in ''latent'' ways and by extension creating variability of response particularly in therapeutics. Correct valency/oxidation state assignment will avail the opportunity for the development of more robust health intervention tools with enhanced predictive response value for progressive science as well as good overall patient outcome both in the inter and intra population level.
Thank you.
Hi,
since hydrogen has therapeutic potentials (regulation of gene expressions and phosphorylations), is the technique applicable for large scale production using lesser demanding methods: since hydrogen is usually produce by the electrolysis of water which is an energy demanding process (although it produces hydrogen without by-products) bringing the need for easier/friendlier methods? Thinking out loud, the hydrogen delivered for therapy should be ready for direct absorption thus penetration without tissue shearing is key in its design making the method described in your paper feasible for use.
Thank you.
Hi,
Great work!!!! Just a quick question on application of oxygen in therapeutics:
how do you control for de-oxygenation in photo-dynamic treatment (PDT)?
On the flip side, people with inborn hemoglobin errors (genetic defects such as sickle cell anemia) for example, can play on technique for corrective measures as well as therapy delivery (my thoughts). This group of people are likely to respond differently to oxygenation for several reasons including malformed red blood cells thus expressing defective signals for oxygen uptake/assimilation. However, with personalized medicine, the oxygen can be conformed in ways that matches the gene defect for efficient uptake and PDT can be applied for diagnostics and therapy delivery.
Lastly, with the highlighted technique in the paper, how to you control for re-dox (reduction and/or oxidation) reactions of the spliced oxygen? Singlet oxygen may not be stable and has the potential of attracting electrons (like/unlike) to its other shell for stabilization thus creating chances of having undesired molecules in your reaction which can play into the composition, precipitation, PH balance and etc of your product. It can also catalyse your reaction making it uncontrollable with chances of a forward/reverse reaction. Is there a need for a control station to work in so as to minimize interference?
Thank you.
Hi Isatou,
Many thanks for the question. The reactive oxygen species (ROS) are highly energetic and will individually have a lifetime on the order of nanoseconds. The lifetime of any residual H2O2, which has some (limited) anti-microbial properties will last somewhat longer, no longer than a few minutes, depending on environmental conditions (pH / temperature / presence of salts in the water etc ). This is one of the major advantages of this approach compared to chlorination, no toxic chemical residues!
The ROS are generated over the catalyst through reaction between very dilute streams of H2 and O2, rather than being cleaved from the catalyst surface, so as long as both gases are supplied constantly, under ideal conditions, the catalyst will continually generate ROS.
Hi, photoswitching is pivotal in research particularly in equipment that are based on light scattering dynamics/sorting (LSDs). It will be a great utility add-on if LSDs can adjust light type/wavelength to different stimuli so as to avail the opportunity to detect and analyse the unknowns in specimens. It is also applicable (my thinking) in nano-theranostics for adaptability as well as precision in simultaneous diagnostic and therapy delivery. Thank you.
Hi, great technique. Just a question, how stable is the end product over time when continually exposed to changes in atmospheric/environmental composition? I am assuming there are cleaving catalyst of the reactive oxygen specie, if so are they naturally naturally occurring? Thank you.