Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Impacts of environmental conditions, and allelic variation of cytosolic glutamine synthetase on maize hybrid kernel production
The objective of our research program is to better understand and improve nitrogen (N) use efficiency in maize. One of these strategies was to study the impacts of environmental conditions, and allelic variation of the cytosolic glutamine synthetase enzyme on maize hybrid kernel production.
Age-Dependent, Motor Cortex Selective TARDBP Demethylation Unlock the Mystery in Amyotrophic Lateral Sclerosis
Our paper indicates DNA demethylation of the autoregulatory region of TDP-43 interferes with the TDP-43 autoregulation resulting in increasing TDP-43. The DNA demethylation increases in the human motor cortex by age. The tissue-specific, age-dependent demethylation may underlie the nature of ALS.
Building translational understanding of pediatric radiation-induced gliomas, an unmet need in childhood cancer
Pediatric radiation-induced gliomas (RIGs) are high-grade brain tumors caused by radiation kids received for a previous cancer. These incurable tumors have had little research attention. We conducted a study of drivers and potential treatments of RIG in the largest patient sample set ever assembled.
Using phosphatase inhibitor beads coupled with mass spectrometry (PIB-MS) to parse phosphoprotein phosphatase signaling.
In our Nature Protocol, we present step by step instructions on how to make phosphatase inhibitor beads, enrich lysates for phosphoprotein phosphatases, multiplex, phosphopeptide enrich, and analyze samples by mass spectrometry to systematically study the major drivers of protein dephosphorylation.
