Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis
The story started from a simple but unanswered question: what is the cellular function of pseudouridine, the most frequent epitranscriptomic modification, in cancer?
Stromal signal promotes Chromatin Remodeling and BET inhibitor Resistance in Cancer cells
BRD4 has a pro-tumorigenic role but non-cell-autonomous mechanisms of BRD4 activation need to be elucidated. Here the authors unravel a mechanism by which CAFs activate BRD4 and induce resistance to BET inhibitors in cancer cells through IL6/IL8 signaling.
B Cells: At the intersection of enhanced responses to immunotherapy treatments
B cells have strong clinical significance as drivers of antitumor immunity in triple negative breast cancer. While B cells are known to enhance T cell-mediated tumor killing, we have also uncovered a potential regulatory function, in which they suppress myeloid-derived suppressor cells.
