Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Exploiting Temporal Correlation of Fortunate Single Molecules for Background-free Super-resolution Imaging
Fortunate molecules (molecules with long blinking cycles) hold the key to quantitative super-resolution imaging (high SBR and a PAR-shift towards a single molecule limit), a step towards economical, reliable, and universal SMLM.
TSLPR CAR T-cell therapy: A new hope for CRLF2+ ALL, but timing of JAK inhibition is crucial
Acute lymphoblastic leukemia (ALL) with CRLF2 rearrangements in Ph-like and Down syndrome-associated ALL subtypes poses a significant challenge in pediatric oncology. These genetic abnormalities lead to constitutive signaling activation and induce resistance to conventional chemotherapy.
Dissecting the natural history of IDH-mutant gliomas
Our work reveals that as IDH mutant gliomas progress, their cell states and key drivers change.
