Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
The Promise of Oxygen-to-Sulfur Exchange in Amide-Derived Covalent Warheads
We demonstrate the utility of a simple Oxygen-to-Sulfur exchange for covalent warhead design and related applications. Our findings establish this approach as a powerful strategy for fine-tuning covalent reactivity and expanding the chemical toolbox of covalent drug discovery and chemical biology.
Behind the Paper：PRMT5 inhibition sensitizes B cell lymphoma cells to ferroptosis
When I first started working on PRMT5, ferroptosis was not part of the plan. While studying how PRMT5 regulates antioxidant capacity, we uncovered an unexpected link revealing how lymphoma cells actively suppress ferroptosis.
The Goldilocks metabolite: why tissues need just enough L-2-HG
Our study reveals that L-2-hydroxyglutarate (L-2-HG), a metabolite often labeled as “toxic,” also has an essential physiological function in mice.
Why Recovery, Not Stress, May Be the Missing Biology of Resilience
Stress is inevitable, but recovery is conditional. This Behind the Paper piece explains how bioenergetic limits, mitochondrial throughput, and unresolved recovery may shape resilience, aging, and chronic disease.
How PfCoronin, a “helper” protein helps malaria parasites evade artemisinin
Imran Ullah, (Harvard University, USA), Sabrina Absalon (Indiana University School of Medicine, USA) Dyann Wirth, (Harvard University, USA).
