Smokeless tobacco (Shammah) extract: effects on hematological parameters, antioxidant defense mechanisms, and organ health in rats
Smokeless tobacco, is a form of tobacco product consumed without combustion, commonly used in various cultures, particularly in the Middle East and parts of Africa
Lithium ion battery degradation: science takes time just like degradation
The physics of lithium ion battery degradation is complex and path dependent. It is still possible to model with a bottom up approach based upon fundamental understanding. However, it just takes time and a long term strategy.
New Wine in Old Wineskins: The Metabolite, The Disease and The Drug
TNF inhibitors have revolutionized the treatment of patients with autoimmune/autoinflammatory diseases. Here, from the perspective of immune metabolism, this study underlies the therapeutic effects of TNF inhibitors in Behçet’s disease (BD), providing novel insights for TNF inhibitors application.
Structure of human mGlu3-arrestin complex
In this paper, we reported the structures of two mGlu3-βarr1 complex with 2:1 and 2:2 stoichiometries. The mGlu3 in an inactive conformation engages βarr1 through phosphorylated C-terminal tail and intracellular loops.
Teff: The Ancient Grain with a Modern Mission
Teff, an ancient cereal grain that has enormous potential to influence the future of sustainable agriculture and food security. Native to Ethiopia, teff has long been a staple crop, but it has been largely ignored and underutilized on the international scene.
Extending Certified Spectral Fluorescence Standards for the Calibration and Performance Validation of Fluorescence Instruments to the NIR – Closing the Gap from 750 nm to 940 nm with Two Novel NIR Dyes
Fluorescence methods provide spectral, intensity, polarization, and lifetime information, which contain sample- and instrument-specific contributions. Fluorescence data, comparable across instruments and laboratories, require validated calibration procedures and certified fluorescence standards.
Breakthrough in Stereoselective C(sp³)–H Alkylation: Nickel Catalysis Unlocks Efficient Synthesis of Chiral Heterocycles
The Kong group report a Ni-catalyzed enantioselective C(sp³)–H alkylation of saturated heterocycles using olefins, enabling efficient construction of chiral C(sp³)–C(sp³) bonds. Applications include late-stage drug diversification and concise syntheses of bioactive alkaloids.
