Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Neuroscience
The local circadian clock of the prefrontal cortex regulates sleep and mediates the effects of sleep deprivation on mood
The study demonstrates the importance of the molecular clock in the prefrontal cortex (PFC) for the regulation of sleep and the effects of sleep deprivation (SD) on mood. Acute SD affects PFC clockwork, while genetic or pharmacological clock modulation prevents SD action.
Cholesterol Shapes How the Brain’s Neurotransmitter Transporter for Serotonin Works
New research shows that membrane cholesterol fine-tunes serotonin, dopamine, and norepinephrine transporters—affecting neurotransmitter recycling, drug responses, and potentially brain disorders.
Dynamical systems show the flexibility of neural connectivity
Dynamic neural connectivity in C. elegans shows quick habituation, shifts in interneuron connectivity without obvious changes in activity, continuous neural activity underlying discrete behavioral states, and individuality that may translate to more complex brains.
The impact of autoimmune co-morbidities in AQP4-NMOSD and MOGAD.
Aquaporin-4 neuromyelitis optica spectrum disorder (AQP4-NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) can present similarly to Multiple Sclerosis (MS) but presents with unique therapeutic and prognostic challenges.
Epigenetics in Motion: How DNMT1 Steers Interneuron Migration and Identity
This study reveals how DNMT1 shapes cortical development by guiding interneuron migration and fate specification beyond mitosis, uncovering novel postmitotic functions in neurons and highlighting epigenetic mechanisms relevant to neurodevelopmental disorders.
