Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Neuroscience
Unravelling the Brain’s Safety Net: From DNA Methylation to Behaviour
How does a molecular change in inhibitory neurons affect the wider brain? We followed the effects of DNMT1 loss from altered neuronal activity to changes in glial cells, perineuronal nets and behaviour, revealing how closely neurons depend on their surrounding cellular environment.
Identifying and Addressing Gaps in Recognition of Cerebral/Cortical Visual Impairment Risk in the NICU
Cerebral/ Cortical visual impairment is often recognized years after the brain injury that caused it. Yet many children at greatest risk can be identified before they ever leave the NICU. We asked a simple question: could we move CVI recognition upstream?
Beyond Ventricular Enlargement: Uncovering Neuroinflammation and Neuronal Injury in Hydrocephalus
Hydrocephalus causes ventricular enlargement, but its effects extend into surrounding brain tissue. We investigated neuroinflammation, oxidative stress, and neuronal injury in congenital hydrocephalus and whether TRPV4 antagonism could attenuate these changes.
A Closer Look at Neurabin I in Neurodevelopmental Disorders
Functional studies often lag behind genetic discovery. Using human cortical neurons, we uncovered how Neurabin I deficiency disrupts neuronal maturation and function, providing mechanistic insight into PPP1R9A-associated neurodevelopmental disorders.
