Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Neuroscience
How the brain adapts its 2D compass for a 3D world
The brain’s neural compass seems 2D, detecting only left and right head-turns. However, if the head is tilted in 3D, its rotation around the vertical axis also covertly changes its horizontal facing direction. We find that the compass neurons can detect these covert changes and thus avoid errors.
Why Recovery, Not Stress, May Be the Missing Biology of Resilience
Stress is inevitable, but recovery is conditional. This Behind the Paper piece explains how bioenergetic limits, mitochondrial throughput, and unresolved recovery may shape resilience, aging, and chronic disease.
How do humans prepare for disturbances before they happen? : A question behind our study of anticipatory postural control
Anticipatory postural control helps us prepare for instability before it happens. Our study suggests that this process is not merely reactive, but is shaped by prediction, optimization, and the active use of gravity.
Dual-vector rAAVrh8 gene therapy for GM2 Gangliosidosis: a Phase I/II trial
This is a dose escalation of a dual AAV vector gene therapy for Tay-Sachs and Sandhoff diseases in which a novel bithalamic infusion process was used. The broad distribution of axonal connections of thalamic neurons enables transport of the normal B-hexosaminidase A enzyme throughout the cerebrum.
The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior
Published in Neuropsychopharmacology volume 50, pages1683–1694 (2025)
Key Role of the CRE Sequence in the Per1 Promoter in Mediating the Switch Between Unipolar and Bipolar Depression‐Like Behaviors
Published in Journal of Pineal Research, 2025, https://doi.org/10.1111/jpi.70095