Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Protocols & Methods
The South American Microbiome Archive
South America hosts some of the world’s most biodiverse gut microbiomes, yet remains largely understudied. We built the largest collection of South American gut microbiomes to better understand this diversity and guide future sampling efforts. See what we found and why it matters.
Largest SARS-CoV-2 genomic surveillance study in Pakistan reveals critical variant dynamics and regional evolution patterns
We conducted the largest single SARS-CoV-2 sequencing effort in Pakistan to date, analyzing 1,052 samples from March-October 2021 using Oxford Nanopore Technologies. Our study reveals unprecedented insights into variant evolution, identifies Pakistan as harboring 34% of global AY.108 lineage cases.
Fixing the Broken Promise: FDR-Controlled Framework for Microbial Biomarker Detection
Advances in DNA sequencing have boosted microbiome research, but identifying meaningful microbial changes remains tough due to sparse, compositional, and repeated-measures data. Existing tools either miss true signals or report too many false positives, limiting reliability
A dual-reference modality to effectively enhance the accuracy of genotyping structural variants from short-read sequencing
SVLearn is a machine learning-based SV genotyper leveraging dual-reference genomes to boost read mapping and accuracy. It improves genotyping precision in insertions, performs well at low coverage, and generalizes across species for scalable, cross-species SV analysis.
