Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Protocols & Methods
Recessive ReNU2 syndrome: highly prevalent and potentially treatable
Genetic variants in a small noncoding gene called RNU2-2 are responsible for the most prevalent known recessive neurodevelopmental disorder. It may also be amongst the disorders amenable to treatment with gene replacement therapy.
StaphScope: From a Frustrating Friday Night to a 14-Minute Solution for MRSA Surveillance
It was a Friday night, and I was drowning in fragmented data. To analyze a few MRSA genomes, I needed six different tools, each with conflicting dependencies. That frustration sparked an idea: what if one tool could do it all, in minutes? Welcome to StaphScope.
Single cell snapshot analyses under proper representation reveal that epithelial-mesenchymal transition couples at G1 and G2/M
Numerous computational approaches have been developed to infer cell state transition trajectories from snapshot single-cell data. With the fast-accumulating computational methods that have been developed, several fundamental issues have been rarely investigated, which is the focus of this study.
Visualizing phenotypic heterogeneity in C. difficile gene expression in situ during infection
What happens when you can see bacterial gene expression in situ inside an infected host? By developing fluorescent reporters, we visualized Clostridioides difficile toxin gene expression, revealing unexpected biology that only emerges in the bacterium’s native context of infection.
