Age-Dependent, Motor Cortex Selective TARDBP Demethylation Unlock the Mystery in Amyotrophic Lateral Sclerosis
Our paper indicates DNA demethylation of the autoregulatory region of TDP-43 interferes with the TDP-43 autoregulation resulting in increasing TDP-43. The DNA demethylation increases in the human motor cortex by age. The tissue-specific, age-dependent demethylation may underlie the nature of ALS.
