Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Vernalis and Diamond turbocharge structure-based optimization of compounds
The high throughput crystallography facility at Diamond (XChem) can be combined with screening of crude reaction mixtures to rapidly identify how to improve the affinity of compounds (fragments and hits) binding to a protein to provide new chemical tools or start points for drug discovery.
Hunting wildlife for disease detection
There is an annual harvest of about 4 million cervids in Europe. The harvest is usually selective and regulated by quotas specific to age, sex or size and depending on management objective, but to plan for selective harvest based on ability to detect wildlife disease is new to Europe.
