Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Enumerating the DEL design chemical space
The Chemical drug-able space is very large but new technologies like DNA encoded libraries are sampling a bigger fraction of it. However, we still need to learn how to navigate the DEL chemical space to get the best out of it.
Patient-derived cancer organoids for drug screening
Organoids from cancer patients, including head and neck cancer organoids, allow for a wide range of applications, including screenings of possible anti-cancer therapies.
Phosphine Gas Detected on Venus
Phosphine is a gas that shouldn't be produced or survive in a rocky oxidized planet atmosphere. On Earth phosphine gas is only associated with life.
Written by Sara Seager and Janusz Petkowski.
Catalytic Asymmetric C-Si Bond Activation via Torsional Strain-Promoted Rh-Catalyzed Aryl-Narasaka Acylation
Aryl Narasaka acylation is realized by the catalysis of chiral rhodium complex which is in situ formed of [Rh(CO)2Cl]2 and phosphoramidite ligand. Computational studies show that the storioanl stain is about 12.58 kcal mol-1, which efficiently accelerate the C-Si bond cleavage.
Digital health interventions – how are we going with evidence?
RCTs and variance in clinical outcomes and patient preferences
