Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Back to the basics: unraveling the role of hypoxia in PKA activation
Endocrine tumors frequently show PKA activation even in the absence of mutations in relevant genes. Here we used GH-secreting pituitary tumor cells to discover a novel mechanism through which hypoxia and HIF-1α activate PKA by altering the expression of the regulatory RIIB subunit.
