Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Back to the basics: unraveling the role of hypoxia in PKA activation
Endocrine tumors frequently show PKA activation even in the absence of mutations in relevant genes. Here we used GH-secreting pituitary tumor cells to discover a novel mechanism through which hypoxia and HIF-1α activate PKA by altering the expression of the regulatory RIIB subunit.
Can we treat cancer with the microbiota?
We heard a lot of correlations between microbiota modifications and cancer development, particularly colorectal cancer. Many different species have been associated with the tumor state and some have also demonstrated to be causative as Fusobacterium nucleatum.
Fluorescing frogs and neon newts
Amphibians, one of the world's most imperiled groups of vertebrates, can biofluoresce. Frogs, salamanders, and caecilians can absorb light from their environment and then emit it at different wavelengths, resulting in brilliantly bright greens and other colors.
The study of a novel candidate oncogene-C1orf35 in multiple myeloma
C1orf35 is a gene first cloned and identified in our laboratory, but little is known about its function. We confirmed it a candidate oncogene in the current study, and explored how it promote tumorigenesis.
