Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Pseudotargeted metabolomics: A method for semi-quantitatively monitoring thousand of metabolites
We developed a pseudotargeted metabolomics method, ion-pairs used for MRM are extracted from untargeted mass spectrometry data by using mixtures of samples to be analyzed, semi-quantitative information of each sample is obtained by the MRM without identification of the metabolites.
Lesion Segregation
Pervasive lesion segregation shapes cancer genome evolution, a new paper from The Liver Cancer Evolution Consortium reveals fundamental insights into mutagenesis. The discovery shows how unrepaired DNA damage generates genetic diversity and provides unprecedented views of DNA repair processes.
Beyond 'business-as-usual': using news media and satellites to connect drug trafficking to forest loss
Illicit activity- intentionally hidden behavior- is often left out of quantitative analyses of land changes like forest loss. Creative data approaches-like using news media as a proxy for drug trafficking- can overcome challenges and enable causal analysis.
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
This project was a great human adventure and we hope that our work will facilitate awareness of the risks associated with shift work and all types of chronic circadian stress on health, in particular for the prevention and follow-up of cancers.
