Artificial Intelligence (AI): A Potential Game Changer in Regenerative Orthopedics—A Scoping Review

Regenerative orthopedics is a field of medicine that focuses on helping the body heal itself from orthopedic injuries and ailments. These approaches hold great promise for treating conditions that were previously difficult to manage.
Published in Computational Sciences and Surgery

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Artificial Intelligence (AI): A Potential Game Changer in Regenerative Orthopedics—A Scoping Review - Indian Journal of Orthopaedics

Background and Aims Regenerative orthopedics involves approaches like stem cell therapy, platelet-rich plasma (PRP) therapy, the use of biological scaffold implants, tissue engineering, etc. We aim to present a scoping review of the role of artificial intelligence (AI) in different treatment approaches of regenerative orthopedics. Methods Using the PRISMA guidelines, a search for articles for the last ten years (2013–2024) on PubMed was done, using several keywords. We have discussed the state-of-the-art, strengths/benefits, and limitations of the published research, and provide a useful resource for the way ahead in future for researchers working in this area. Results Using the eligibility criteria out of 82 initially screened publications, we included 18 studies for this review. We noticed that the treatment responses to regenerative treatments depend on several factors; hence, to facilitate better comprehensive and patient-specific treatments, AI technology is very useful. Machine learning (ML) and deep learning (DL) are a few of the most frequently used AI techniques. They use a data-driven approach for training models to make human-like decisions. Data are fed to the ML/DL algorithm and the trained model makes classifications or predictions based on its learning. Conclusion The area of regenerative orthopedics is highly sophisticated and significantly aids in providing cost-effective and non-invasive treatments to patients suffering from orthopedic ailments and injuries. Due to its promising future, the use of AI in regenerative orthopedics is an emerging and promising research field; however, its universal clinical applications are associated with some ethical considerations, which need addressing. Graphical Abstract

The Role of Artificial Intelligence (AI)

The authors explore the use of artificial intelligence (AI) in regenerative orthopedics. AI has the potential to revolutionize this field by:

  • Improving Treatment Decisions: Many factors influence how patients respond to regenerative treatments. AI can analyze large datasets of patient information to identify patterns and predict the most effective treatment options for each individual.
  • Machine Learning and Deep Learning: These AI techniques are particularly powerful. They use a data-driven approach to train models that can make decisions similar to humans. By feeding data into these algorithms, they can learn and make predictions based on their learnings.

Looking Ahead: The Future of AI in Orthopedics

The use of AI in regenerative orthopedics is a rapidly growing field with immense potential. However, there are also some challenges to consider:

  • Ethical Considerations: As with any new technology, ethical considerations around data privacy and the use of AI in healthcare need to be addressed.
  • Need for More Research: While promising, AI applications in regenerative orthopedics are still under development. More research is required to ensure its effectiveness and safety in clinical settings.


Regenerative orthopedics offers exciting possibilities for treating various musculoskeletal conditions. AI has the potential to significantly enhance this field by personalizing treatment plans and improving patient outcomes. As research progresses and ethical considerations are addressed, AI is poised to become a true game changer in regenerative orthopedics.

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