Cerebrovascular diseases are among the leading causes of mortality and long-term disability globally. Understanding the intricate relationship between vascular dysfunction and neural mechanisms is essential for developing targeted interventions and advancing precision medicine in stroke, vascular cognitive impairment, and intracranial aneurysms.

This collection in Discover Neuroscience seeks to highlight cutting-edge research that integrates genetics, multiomics, and translational approaches to uncover the neural mechanisms underlying cerebrovascular diseases. We invite contributions that explore how vascular dysfunction influences neural circuitry, cognitive processes, neuroinflammation, and neurodegeneration, as well as studies leveraging omics technologies and computational neuroscience to dissect disease mechanisms and identify novel therapeutic targets.

Topics of Interest include, but are not limited to:

• Neurogenetics and neurogenomics of cerebrovascular diseases, including genome-wide association studies, polygenic risk scores, and rare variant analysis

• Multiomic approaches such as transcriptomics, epigenomics, proteomics, and metabolomics to understand pathophysiological mechanisms, identify biomarkers, and develop targeted therapies for cerebrovascular diseases

• Neurovascular interactions in stroke and vascular cognitive impairment

• Role of neuroinflammation and immune responses in cerebrovascular diseases

• Experimental studies using animal and cellular models, or organoids to investigate cerebrovascular pathophysiology and potential therapies

• Blood-brain barrier dysfunction as a pathogenic mechanism in cerebrovascular diseases and its consequences for neuronal injury, inflammation, and long-term neurological outcomes

• Neural network alterations following cerebrovascular events through functional and structural neuroimaging or connectomics

• Synaptic plasticity and recovery mechanisms after ischemic injury

• Computational and machine learning approaches for predicting cerebrovascular disease progression and risk stratification

• Neurovascular mechanisms underlying cerebrovascular contributions to cognitive impairment and dementia, including vascular dementia and mixed pathologies

• Biomarker discovery and therapeutic interventions in cerebrovascular disorders

Keywords: Cerebrovascular diseases, neurovascular disorders, stroke, vascular dementia, multiomics, genetics, models, neuroplasticity, functional genomics, neural mechanisms

Stroke remains a major global health challenge, ranking as the second leading cause of death and the third leading cause of disability worldwide. Every minute of delay in treatment results in irreversible neuronal loss. This collection seeks to showcase multidisciplinary scholarship on the clinical management of acute stroke, from prevention to recovery, and invites studies that span the continuum of care.

Topics of interest include, but are not limited to:

1. Risk Factors: Identification and modification of traditional and emerging stroke risk factors.

2. Prevention Strategies: Primordial, primary, and secondary prevention approaches tailored to diverse populations.

3. Clinical Therapies: Innovations in thrombolysis, mechanical thrombectomy, and endovascular treatments.

4. Neurocritical Care: Protocols for acute management in neurocritical care units, including monitoring and complication prevention.

5. Rehabilitation and Outcomes: Functional recovery strategies, neuroplasticity, and management of long-term cognitive and motor deficits.

Please note that papers on cardiovascular aspects without a focus on stroke will not be considered.

Keywords: Acute Stroke, Clinical Management, Stroke Risk Factors, Medical Care, Therapy.