Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
This study presents an optimized proteogenomic workflow for the discovery of neoantigens (in particular RNA-derived neoantigens) in a pan-cancer cohort and sheds light on the entity-agnostic prevalence of HLA-I peptide presentation of RNA processing events for tumor targeting.
One step closer to an Implantable Artificial Kidney
Our team at The Kidney Project chose a biohybrid approach to tissue engineering a universal donor kidney that mimics the tandem filtration-concentration physiology of a healthy kidney. Here, we show that cellular scaffolds can double as immunological barriers between host and allogeneic cells.
Revealing the contrasting roles of soil moisture−atmosphere feedbacks in modulating the abrupt transition from drought to pluvial conditions
There is a significant increase in the occurrence of drought and pluvial transitions globally during 1980−2020. We find that the transitive causal chains induced by land−atmosphere feedbacks play an important role in triggering the occurrence of drought and pluvial transitions.
Pacific Decadal Oscillation causes fewer near-equatorial cyclones in the north Indian Ocean
Our study finds a remarkable 43% decline in the frequency of low-latitude cyclones (LLCs, originating between 5°N and 11°N) during the post-monsoon season in the north Indian Ocean (NIO) in recent decades (1981-2010) compared to earlier decades (1951-1980).
Therapeutic phages that infect mycobacteria require cell-surface trehalose polyphleates
Trehalose polyphleates- very large, surface-exposed molecules- are required for infection of several phages used as therapy against opportunistic pathogen Mycobacterium abscessus.
Changes of phosphorus reactivity in the Yellow River from source to estuary
We published our paper in Communications Earth & Environment in late August 2023. We spent two years collecting water samples from 72 stations in the whole Yellow River to investigate changes in reactivity of dissolved and suspended particulate phosphorus under long-distance transport.
