Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
TISSUE: Predicting missing spatial gene expression with confidence
Several computational methods have been developed to augment spatially resolved single-cell transcriptomics to measure more genes. We developed TISSUE to build on these methods by providing confidence in these computational measurements and additional tools for performing data analysis.
Decoding Radiation-Induced Fibrosis: a computational approach to understanding the damage pathway
Computational modeling of radiation-induced lung fibrosis via the agent-based paradigm provides valuable insights into the initiation and progression of toxicity.
A Detour for Prostate Cancer Cell Survival and Growth
Second generation AR antagonists, abiraterone and enzalutamide, induce aberrant HGF/MET and Wnt pathways leading to increased XPO1 expression and ribosomal biosynthesis in double-null prostate cancer (DNPC). However, treatment with XPO1 and ribosomal inhibitors showed an improved antitumor response.