Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
The role of the stroma, encompassing pancreatic stellate cells and extracellular matrix, in the biology and chemoresistance of pancreatic cancer
Our report entitled “3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing” (PMID: 23446043) has its ten years anniversary. Herein we present the story "After the Paper" on the background of two recent publication from our group.
A protein hindered from folding by its parent ribosome
Cassaignau and colleagues use NMR to reveal how a dynamic elongating nascent polypeptide interacts with the ribosome to modulate its folding (https://www.nature.com/articles/s41557-021-00796-x)
An Unlikely Tale: How a Paper on Hemostasis, Puncture Wounds and Platelets Came from a Team Led by Ph.D.s in Physics and Biochemistry
Puncture wounds and how platelet leads to bleeding cessation is not normally thought of as problem in cell and developmental biology. Here a team trained in physics and biochemistry take exactly that approach to thrombus structure and how that leads to bleeding cessation in ta jugular wound.
