Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Selecting the most appropriate SpCas9 variants for your own interests
Among the numerous SpCas9 variants that previously reported, we compared 13 variants to provide guidance to researchers. We developed a computational tool that predicts the activities of the variants to provide insights in selecting the most appropriate variants for their own research purposes.
Synthesis and versatile reactivity of scandium phosphinophosphinidene complexes
Due to the energy mismatching between the frontier orbitals of rare-earth metal and ligand atom, the rare-earth metal-phosphorus multiple bonds are very unstable. This Behind introduces our group’s struggling trip to the first rare-earth monometallic phosphinidene complex during the past 10 years.
50 Years of Cetacean Strandings Reveal a Concerning Rise in Chilean Patagonia
By collecting cetacean stranding data from the last 50 years in the Chilean coast, we found that strandings have been increasingly reporting at a higher rate during the last 10 years, particularly at the Patagonia, the southernmost part of Chile.
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
Ewing sarcoma is a pediatric cancer characterized by chimeric EWSR1-ETS fusion oncogenes (in 85% EWSR1-FLI1). In our recent study, we showed that EWSR1-FLI1 hijacks the developmental transcription factor SOX6, which contributes to tumor growth but also increases sensitivity toward oxidative stress.
