Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces
Pharmaceutically important polyketides are produced during the stationary phase of growth of Streptomyces species in fermenters. The source of intracellular metabolites that are funneled into polyketide biosynthesis has proven elusive. We uncover the mystery and devised a titer improvement strategy.
Reversing cancer immune exclusion with PAK4 inhibition
Gabriel Abril-Rodriguez and Antoni Ribas
Conserving Floodplains to Mitigate Future Flood Risk
Protecting undeveloped lands in areas at risk for flooding avoids needlessly placing more people and property in harm's way and can reduce future flood damages while also preserving habitat, improving water quality and providing a range of other valuable benefits.